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Muscle Relaxants Toxicity Toxicology

Muscle Relaxants Toxicity Toxicology

If you experience neck or back strains, you may be recommended a muscle relaxant like Zanaflex or Flexeril. These drugs can also help relieve muscle spasms and stiffness related to other physical conditions and injuries. Some of the popular and commonly prescribed muscle relaxants are briefly described below.

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Both tizanidine and cyclobenzaprine can cause problems if you take them when you have certain other health issues. You should avoid using cyclobenzaprine does flexeril show up on drug screen if you have a slow heart rhythm or heart rhythm problems. In some circumstances, tizanidine might be used safely in this case.

For example, they are used to treat muscle spasms caused by conditions such as acute low back pain, tension headaches, and fibromyalgia. Some of the muscle relaxants used to reduce muscle spasms include cyclobenzaprine, methocarbamol, carisoprodol, metaxalone, chlorzoxazone, and orphenadrine. In general, doctors prescribe a locally or centrally-acting muscle relaxant to treat muscle spasms only after other treatments have failed. However, depending on the severity, you may need to take medications called skeletal muscle relaxants to treat muscle spasms that are beyond at-home treatments. While both medications are muscle relaxers, they differ in side effects, risks, and what they are used to treat. For example, Zanaflex (tizanidine) is used to treat muscle spasticity linked to MS and spinal cord injuries while cyclobenzaprine is used to treat skeletal muscle pain and spasms.

What Is The Difference Between Cyclobenzaprine And Tizanidine?

You should never take both medications together as you significantly increase the severity of side effects, including the risk of experiencing a muscle relaxer overdose. In comparison, Tizanidine is more direct – blocking the nerve signals in the brain, reducing activity of the muscles that cause muscles to spasm. Flexeril, on the other hand, is not recognized by medical professionals as addictive, but there is evidence that it may be possible to get addicted to it.

It is usually well tolerated, but attention must be given to avoid abrupt discontinuation. There is relatively more experience with baclofen treatment in CP, specifically for spasticity. Evidence supporting baclofen use is mostly anecdotal, and there is no significant body of evidence to support routine use currently. Adverse effects that were less common, found in 1–3% of patients, were abdominal pain, reflux, diarrhea, constipation, upper respiratory infection, dizziness, irritability, pharyngitis, nausea, nervousness. Of note, any medication with a side effect profile of drowsiness should be used with caution in the elderly, as this can lead to increased numbers of falls as well as impaired cognition.

Prolonged or misused Flexeril can result in withdrawal symptoms and other adverse effects. Individuals need to follow their healthcare provider’s instructions, use the medication as prescribed, and communicate any concerns or changes in symptoms promptly. Consulting a healthcare professional is crucial for proper guidance and monitoring when using Flexeril to minimize the risk of addiction.

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Cyclobenzaprine has been evaluated in most clinical trials with evidence to support its usage, according to a meta-analysis. Tizanidine has been shown to help with spasticity caused by multiple sclerosis. For musculoskeletal problems, such as acute neck or back pain, both cyclobenzaprine and tizanidine were proven to be helpful. Tizanidine (Zanaflex) and Flexeril (Cyclobenzaprine) are both muscle relaxants. They are used by medical personnel to treat muscle tightness arising from painful musculoskeletal conditions and injuries.

  • Some evidence support its efficacy and it may be as effective as diazepam.
  • Current evidence points to an improvement in muscle tone and strength with oral baclofen use, although this effect may be short-term and prolonged use may cause increased weakness in patients.
  • The FDA also states that overdose is a concern with the use of this drug.
  • In high doses, Flexeril can produce calming and pain-relieving effects that are desirable by some people, and this is part of the reason it was only meant to be used for short periods of time.
  • If you experience neck or back strains, you may be recommended a muscle relaxant like Zanaflex or Flexeril.

The potential adverse effects should be communicated clearly to the patient. Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions. CP is a permanent, chronic, non-progressive neuromuscular and neurocognitive disorder of motor dysfunction that is diagnosed in infancy and is frequently (62% of patients) accompanied by chronic or recurrent muscular pain.

Zanaflex (tizanidine) is a skeletal muscle relaxant used for the treatment and management of skeletal muscle spasticity, typically resulting from neurological problems. It works on alpha 2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles, which produces muscle relaxation. Zanaflex (tizanidine) and Flexeril (cyclobenzaprine) are muscle relaxants used to treat painful musculoskeletal conditions.


Short-term use of skeletal muscle relaxants may be appropriate for certain conditions but should not be used long-term, regardless of interaction. Nonpharmacologic therapy may be a better option in both the short term and the long term. Nonpharmacologic education on fall prevention is essential in patients being given skeletal muscle relaxants, regardless of duration of therapy. Not only will appropriate use of skeletal muscle relaxants improve patient outcomes, it can also improve star ratings for both insurance providers and pharmacies. Flexeril, or cyclobenzaprine, is a significantly useful medication in the treatment of peripheral muscle spasm and pain in acute muscle injury.